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Article

Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2007

Abu-Bakar A'edah, Lämsä Virpi, Arpiainen Satu, Moore Michael R, Lang Matti A, Hakkola Jukka

Abstract excerpt

We have previously shown that cadmium, a metal that alters cellular redox status, induces CYP2A5 expression in nuclear factor (erythroid-derived 2)-like 2 wild-type (Nrf2+/+) mice but not in the knockout (Nrf2-/-) mice. In the present studies, the potential role of Nrf2 in cadmium-mediated regulation of Cyp2a5 gene was investigated in mouse primary hepatocytes. Cadmium chloride (CdCl2) caused a time-dependent...

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Identifiers

PMID: 17303623
DOI: 10.1124/dmd.106.014423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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