Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Nrf2 in the regulation of the <i>Mrp2</i> (<i>ABCC2</i>) gene

11 Apr 2006

Abstract excerpt

The Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) transcription factor regulates gene expression of the GCLC (glutamate-cysteine ligase catalytic subunit), which is a key enzyme in glutathione synthesis, and GSTs (glutathione S-transferases) via the ARE (antioxidant-response element). The Mrp2 (multidrug-resistance protein 2) pump mediates the excretion of GSH and GSSG excretion as well as endo- and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Genomics, phytochemicals, and oxidative stress
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16426233
DOI: 10.1042/bj20051518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Nrf2 in the regulation of the <i>Mrp2</i> (<i>ABCC2</i>) genePMID 16426233Read ↗

Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.Semantic proximity Read ↗

Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer.Semantic proximity Read ↗

Distinct mechanisms by which antioxidant transcription factors Nrf1 and Nrf2 as drug targets contribute to the anticancer efficacy of Cisplatin on hepatoma cellsSemantic proximity Read ↗

Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.Semantic proximity Read ↗

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.Semantic proximity Read ↗

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.Semantic proximity Read ↗

Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype.Semantic proximity Read ↗

Role of Nrf2 in cancer photodynamic therapy: regulation of human ABC transporter ABCG2.Semantic proximity Read ↗

Export pumps for glutathione S-conjugates.Semantic proximity Read ↗

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.Semantic proximity Read ↗

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.Semantic proximity Read ↗

Transport of glutathione and glutathione conjugates by MRP1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.