Article
Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells.
Biochimica et biophysica acta - 6 Jun 2001
Kim J Y, Kanai Y, Chairoungdua A, Cha S H, Matsuo H, Kim D K, Inatomi J, Sawa H, Ida Y, Endou H
Abstract excerpt
A human cDNA for amino acid transport system x(C)(-) was isolated from diethyl maleate-treated human glioma U87 cells. U87 cells expressed two variants of system x(C)(-) transporters hxCTa and hxCTb with altered C-terminus regions probably generated by the alternative splicing at 3'-ends. Both hxCTa and hxCTb messages were also detected in spinal cord, brain and pancreas, although the level of hxCTb expression...
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