Article
RPD3 is required for the inactivation of yeast ribosomal DNA genes in stationary phase.
The EMBO journal - 16 Sept 2002
Sandmeier Joseph J, French Sarah, Osheim Yvonne, Cheung Wang L, Gallo Christopher M, Beyer Ann L, Smith Jeffrey S
Abstract excerpt
rRNA transcription in Saccharomyces cerevisiae is performed by RNA polymerase I and regulated by changes in growth conditions. During log phase, approximately 50% of the ribosomal DNA (rDNA) genes in each cell are transcribed and maintained in an open, psoralen-accessible conformation. During stationary phase, the percentage of open rDNA genes is greatly reduced. In this study we found that the Rpd3 histone...
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