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Article

DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.

PLoS genetics - 28 Oct 2010

Drouin Simon, Laramée Louise, Jacques Pierre-Étienne, Forest Audrey, Bergeron Maxime, Robert François

Abstract excerpt

Histone deacetylase Rpd3 is part of two distinct complexes: the large (Rpd3L) and small (Rpd3S) complexes. While Rpd3L targets specific promoters for gene repression, Rpd3S is recruited to ORFs to deacetylate histones in the wake of RNA polymerase II, to prevent cryptic initiation within genes. Methylation of histone H3 at lysine 36 by the Set2 methyltransferase is thought to mediate the recruitment of Rpd3S....

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PMID: 21060864
DOI: 10.1371/journal.pgen.1001173
PMCID: PMC2965751

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DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.PMID 21060864Read ↗

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.Semantic proximity Read ↗

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.Semantic proximity Read ↗

Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.Semantic proximity Read ↗

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.Semantic proximity Read ↗

Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.Semantic proximity Read ↗

A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.Semantic proximity Read ↗

Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin.Semantic proximity Read ↗

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.Semantic proximity Read ↗

Genome-wide binding map of the histone deacetylase Rpd3 in yeast.Semantic proximity Read ↗

Phosphorylation of the RNA polymerase II C-terminal domain dictates transcription termination choice.Semantic proximity Read ↗

The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development.Semantic proximity Read ↗

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.Semantic proximity Read ↗

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