Article
DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.
PLoS genetics - 28 Oct 2010
Drouin Simon, Laramée Louise, Jacques Pierre-Étienne, Forest Audrey, Bergeron Maxime, Robert François
Abstract excerpt
Histone deacetylase Rpd3 is part of two distinct complexes: the large (Rpd3L) and small (Rpd3S) complexes. While Rpd3L targets specific promoters for gene repression, Rpd3S is recruited to ORFs to deacetylate histones in the wake of RNA polymerase II, to prevent cryptic initiation within genes. M...
Topics
- Chromatin Immunoprecipitation
- Chromosomal Proteins, Non-Histone
- Cyclin-Dependent Kinases
- Gene Expression Profiling
- Gene Expression Regulation, Fungal
- Histone Deacetylases
- Histones
- Isoenzymes
- Lysine
- Methylation
- Methyltransferases
- Mutation
- Nuclear Proteins
- Oligonucleotide Array Sequence Analysis