Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.

doi:10.1016/j.cell.2005.10.023

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Article

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.

Cell - 18 Nov 2005

Carrozza Michael J, Li Bing, Florens Laurence, Suganuma Tamaki, Swanson Selene K, Lee Kenneth K, Shia Wei-Jong, Anderson Scott, Yates John, Washburn Michael P, Workman Jerry L

Abstract excerpt

Yeast Rpd3 histone deacetylase plays an important role at actively transcribed genes. We characterized two distinct Rpd3 complexes, Rpd3L and Rpd3S, by MudPIT analysis. Both complexes shared a three subunit core and Rpd3L contains unique subunits consistent with being a promoter targeted corepressor. Rco1 and Eaf3 were subunits specific to Rpd3S. Mutants of RCO1 and EAF3 exhibited increased acetylation in the...

Topics

Acetylation
Acetyltransferases
Chromatin Immunoprecipitation
Gene Expression Regulation, Fungal
Histone Deacetylases
Histones
MAP Kinase Kinase Kinases
Methylation
Methyltransferases
Molecular Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Open Reading Frames

Promoter Regions, Genetic

Protein Binding

Protein Subunits

Repressor Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed

Identifiers

PMID: 16286007
DOI: 10.1016/j.cell.2005.10.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16286007-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.PMID 16286007Read ↗

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.Semantic proximity Read ↗

DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.Semantic proximity Read ↗

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