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Article

Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Oct 1999

Kim S, Benguria A, Lai C Y, Jazwinski S M

Abstract excerpt

The yeast Saccharomyces cerevisiae has a limited life-span, which is measured by the number of divisions that individual cells complete. Among the many changes that occur as yeasts age are alterations in chromatin-dependent transcriptional silencing. We have genetically manipulated histone deacetylases to modify chromatin, and we have examined the effect on yeast longevity. Deletion of the histone deacetylase...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Source

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Identifiers

PMID: 10512855
DOI: 10.1091/mbc.10.10.3125
PMCID: PMC25567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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