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Article

RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability.

RNA biology - 1 Jan 2024

Normand Christophe, Dez Christophe, Dauban Lise, Queille Sophie, Danché Sarah, Abderrahmane Sarra, Beckouet Frederic, Gadal Olivier

Abstract excerpt

Transcription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome. RNA polymerase I (RNAPI) is responsible for massive rRNA production, and nascent rRNA is co-transcriptionally assembled with early assembly factors in the yeast nucleolus. In Saccharomyces cerevisiae, a mutant form of RNAPI bearing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39049162
DOI: 10.1080/15476286.2024.2381910
PMCID: PMC11275518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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