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Article

Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.

Molecular psychiatry - 1 Jan 2002

Laws S M, Hone E, Taddei K, Harper C, Dean B, McClean C, Masters C, Lautenschlager N, Gandy S E, Martins R N

Abstract excerpt

The apolipoprotein E (APOE, gene; apoE, protein) type 4 isoform is a well-established risk factor for late-onset Alzheimer's disease (AD), and new data suggest that APOE promoter polymorphisms might also modulate AD risk, perhaps by altering transcription of the APOE gene. The current study was undertaken to determine whether the presence of the APOE promoter -491AA genotype (that appears to increase the risk for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12232782
DOI: 10.1038/sj.mp.4001097

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.PMID 12232782Read ↗

The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.Semantic proximity Read ↗

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

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The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease.Semantic proximity Read ↗

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.Semantic proximity Read ↗

Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.Semantic proximity Read ↗

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Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.Semantic proximity Read ↗

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Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions.Semantic proximity Read ↗

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