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Article

The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease.

Neuroscience letters - 26 Mar 1999

Ahmed A R, MacGowan S H, Culpan D, Jones R W, Wilcock G K

Abstract excerpt

Several studies have attempted to confirm the association between the recently reported polymorphism located at position -491 in the transcriptional regulatory region of the Apolipoprotein E (ApoE) gene and Alzheimer's disease (AD). Results have been inconclusive, possibly due to the use of clini...

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PMID: 10213175
DOI: 10.1016/s0304-3940(99)00126-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10213175-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease.PMID 10213175Read ↗

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.Semantic proximity Read ↗

The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.Semantic proximity Read ↗

The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.Semantic proximity Read ↗

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.Semantic proximity Read ↗

The --491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis.Semantic proximity Read ↗

Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.Semantic proximity Read ↗

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease.Semantic proximity Read ↗

Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.Semantic proximity Read ↗

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients.Semantic proximity Read ↗

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