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Article

Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes.

Human molecular genetics - 15 Nov 2004

Bray Nicholas J, Jehu Luke, Moskvina Valentina, Buxbaum Joseph D, Dracheva Stella, Haroutunian Vahram, Williams Julie, Buckland Paul R, Owen Michael J, O'Donovan Michael C

Abstract excerpt

The epsilon4 haplotype of APOE is the only undisputed genetic risk factor for late-onset Alzheimer's disease (LOAD). It has been proposed that at least two other polymorphisms in the promoter of the APOE gene (-219G>T and -491A>T) might also contribute to disease susceptibility, and modulate the impact of structural changes in the ApoE protein, by altering its expression. In order to assess the extent of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15385439
DOI: 10.1093/hmg/ddh299

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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