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Article

Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.

American journal of medical genetics - 8 Jul 2002

Roks G, Cruts M, Houwing-Duistermaat J J, Dermaut B, Serneels S, Havekes L M, Hofman A, Breteler M M B, Van Broeckhoven C, van Duijn C M

Abstract excerpt

The apolipoprotein E (APOE) gene is involved in lipid transport. A common polymorphism in this gene with the APOE*2, APOE*3, and APOE*4 alleles influences plasma levels of apolipoprotein E and cholesterol. Besides its role in lipid transport, the APOE*4 allele is a genetic risk factor for Alzheimer disease (AD). Recently, a polymorphism in the APOE promoter region was found to be involved in plasma apolipoprotein...

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Source

Identifiers

PMID: 12116196
DOI: 10.1002/ajmg.10407

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.PMID 12116196Read ↗

The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.Semantic proximity Read ↗

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The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease.Semantic proximity Read ↗

Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.Semantic proximity Read ↗

Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis.Semantic proximity Read ↗

The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism.Semantic proximity Read ↗

The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.Semantic proximity Read ↗

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Serum apolipoprotein E level is not increased in Alzheimer's disease: the Rotterdam study.Semantic proximity Read ↗

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.Semantic proximity Read ↗

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

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