Article
Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women.
Calcified tissue international - 1 Nov 2002
Jørgensen H L, Madsen J S, Madsen B, Saleh M M A, Abrahamsen B, Fenger M, Lauritzen J B
Abstract excerpt
Twin studies indicate a substantial genetic component in the development of osteoporosis. One of the latest studied candidate genes is the one coding for methylene tetrahydrofolate reductase (MTHFR) (C677T) in which a point mutation gives rise to a thermolabile variant of MTHFR. The aim of this study was to investigate the influence of this mutation on peripheral measures of bone density and on the odds ratios...
Topics
- Aged
- Alleles
- Bone Density
- Calcaneus
- Case-Control Studies
- DNA
- DNA Mutational Analysis
- Denmark
- Female
- Forearm Injuries
- Genetic Predisposition to Disease