Association between the methylenetetrahydrofolate reductase c.677C>T polymorphism and bone mineral density: an updated meta-analysis.

doi:10.1007/s00438-015-1101-z

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Article

Association between the methylenetetrahydrofolate reductase c.677C>T polymorphism and bone mineral density: an updated meta-analysis.

Molecular genetics and genomics : MGG - 1 Feb 2016

Li Hong-Zhuo, Wang Wei, Liu Yi-Ling, He Xiao-Feng

Abstract excerpt

Many studies have reported an association between the methylenetetrahydrofolate reductase (MTHFR) c.677C>T polymorphism and reduced bone mineral density (BMD), but results have been inconsistent. We, therefore, performed a meta-analysis to further explore this association. Twenty-one studies, comprising 33,045 subjects, analyzed the association of MTHFR c.677C>T with femoral neck BMD. Significant association with...

Topics

Adult
Aged
Aged, 80 and over
Bone Density
Cohort Studies
Female
Femur Neck
Genetic Predisposition to Disease
Humans
Lumbar Vertebrae
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Polymorphism, Genetic

Postmenopause

Risk Factors

White People

Young Adult

Source

Open in PubMed

Identifiers

PMID: 26231982
DOI: 10.1007/s00438-015-1101-z

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26231982-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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