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The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures

2020-06-14

Abstract excerpt

<p>A functional polymorphism in methylenetetrahydrofolatereductase (MTHFR) has been identifi ed at codon677 (C677T). The T-allele variant (valine type) has lowerenzyme activity than the wild type (C-allele or alaninetype), resulting in a slightly elevated homocysteine level,which has been recently recognized as a risk factor for fracture.However, whether subjects bearing the T allele havehigher susceptibility to f...

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Literature Corpus work
0efef92b-53fd-5fdb-ae4f-f2bc9fcf44c6
DOI
10.31234/osf.io/taq7f
Open publication

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