Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2004

McLean Robert R, Karasik David, Selhub Jacob, Tucker Katherine L, Ordovas Jose M, Russo Giuseppina T, Cupples L Adrienne, Jacques Paul F, Kiel Douglas P

Abstract excerpt

UNLABELLED: A study of a polymorphism in the MTHFR gene, plasma folate, and bone phenotypes in 1632 individuals revealed that the genotype effect on BMD and quantitative ultrasound was dependent on the level of folate. Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status. INTRODUCTION: Genome-wide screens using quantitative ultrasound...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Bone and Bones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bone Density

Share to MTHFR gene

Share to Homocysteine

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Phenotype

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 15040829
DOI: 10.1359/JBMR.0301261

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status.PMID 15040829Read ↗

Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.Semantic proximity Read ↗

The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women.Semantic proximity Read ↗

Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD.Semantic proximity Read ↗

Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study.Semantic proximity Read ↗

Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women.Semantic proximity Read ↗

Association between the methylenetetrahydrofolate reductase c.677C>T polymorphism and bone mineral density: an updated meta-analysis.Semantic proximity Read ↗

Association of MTHFR C667T polymorphism with bone mineral density and fracture risk: an updated meta-analysis.Semantic proximity Read ↗

Association between methylenetetrahydrofolate reductase C677T polymorphism and bone mineral density: the Dong-gu Study and the Namwon Study.Semantic proximity Read ↗

Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study.Semantic proximity Read ↗

Polymorphism of SLC25A32, the folate transporter gene, is associated with plasma folate levels and bone fractures in Japanese postmenopausal women.Semantic proximity Read ↗

Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.