Article
Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2004
McLean Robert R, Karasik David, Selhub Jacob, Tucker Katherine L, Ordovas Jose M, Russo Giuseppina T, Cupples L Adrienne, Jacques Paul F, Kiel Douglas P
Abstract excerpt
UNLABELLED: A study of a polymorphism in the MTHFR gene, plasma folate, and bone phenotypes in 1632 individuals revealed that the genotype effect on BMD and quantitative ultrasound was dependent on the level of folate. Our findings support the hypothesis that the association between an MTHFR poly...
Topics
- Biomarkers
- Bone Density
- Bone and Bones
- Female
- Folic Acid
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Phenotype
- Polymorphism, Genetic
- Ultrasonography