Article
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Apr 2005
Villadsen Morten M, Bünger Mathias H, Carstens Mette, Stenkjaer Liselotte, Langdahl Bente L
Abstract excerpt
Osteoporosis is a common disease with a strong genetic component. Linkage studies have suggested linkage between BMD and loci on chromosome 1. The MTHFR gene is located on chromosome 1. MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methylenetetrahydrofolate, which is used...
Topics
- Adult
- Aged
- Aged, 80 and over
- Bone Density
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Linear Models
- Lumbar Vertebrae
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)