Association of MTHFR C667T polymorphism with bone mineral density and fracture risk: an updated meta-analysis.

doi:10.1007/s00198-011-1885-6

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Article

Association of MTHFR C667T polymorphism with bone mineral density and fracture risk: an updated meta-analysis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Nov 2012

Wang H, Liu C

Abstract excerpt

UNLABELLED: This meta-analysis investigated the association of C677T polymorphism in MTHFR gene with bone mineral density (BMD) and fracture risk. The results suggested that C677T polymorphism was marginally associated with fracture risk. In addition, this polymorphism was modestly associated wit...

Topics

Aged
Bone Density
Female
Femur Neck
Genetic Predisposition to Disease
Hip Joint
Humans
Lumbar Vertebrae
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Osteoporosis
Osteoporotic Fractures
Polymorphism, Single Nucleotide
Publication Bias

Source

Open in PubMed

Identifiers

PMID: 22187009
DOI: 10.1007/s00198-011-1885-6

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22187009-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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