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Article

Quantitative assessment of the associations between MTHFR C677T and A1298C polymorphisms and risk of fractures: a meta-analysis.

Molecular biology reports - 1 Mar 2013

Bai Rui, Liu Wanlin, Zhao Aiqing, Zhao Zhenqun, Jiang Dianming

Abstract excerpt

Many studies have investigated the associations between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and risk of fractures, but the impact of MTHFR polymorphisms on fractures risk is unclear owing to the obvious inconsistence among those studies. This study aims to quantify the strength of association between MTHFR C677T and A1298C polymorphisms and risk of fractures. We searched the...

Topics

Alleles
Amino Acid Substitution
Case-Control Studies
Fractures, Bone
Genetic Predisposition to Disease
Genotype
Hip Fractures
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Odds Ratio

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Publication Bias

Risk

Spinal Injuries

Source

Identifiers

PMID: 23229495
DOI: 10.1007/s11033-012-2322-4

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23229495-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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