Article
A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2003
Abrahamsen Bo, Madsen Jonna Skov, Tofteng Charlotte Landbo, Stilgren Lis, Bladbjerg Else Marie, Kristensen Søren Risom, Brixen Kim, Mosekilde Leif
Abstract excerpt
A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) has recently been associated with bone mineral density (BMD) in postmenopausal Japanese women. It is not known whether this effect is also present in European populations and whether it is caused by lower peak bone ma...
Topics
- Alleles
- Bone Density
- Denmark
- Estrogen Replacement Therapy
- Female
- Fractures, Bone
- Gene Frequency
- Genotype
- Humans
- Longitudinal Studies
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged