Article
Mouse skin as a model for cancer chemoprevention by nonsteroidal anti-inflammatory drugs.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer - 1 Jan 2003
Marks Friedrich, Fürstenberger Gerhard, Neufang Gitta, Müller-Decker Karin
Abstract excerpt
The mouse skin model of multistage carcinogenesis has demonstrated that cancer results from a synergism between genotoxic and nongenotoxic factors. The former induce irreversible genetic alterations, whereas the latter promote tumor development by favoring the clonal outgrowth of the genetically altered cells. While therapeutic gene repair is a still unrealized dream, tumor promotion provides an attractive target...
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