Article
Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Apr 1994
Jhappan C, Takayama H, Dickson R B, Merlino G
Abstract excerpt
The epidermal growth factor receptor (EGFR), which mediates the mitogenic activity of transforming growth factor alpha (TGF-alpha), has been shown to activate Ras in cultured cells through well-defined intermediary proteins. To examine the in vivo relationship between EGFR and Ras, chemical carci...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Base Sequence
- ErbB Receptors
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Mice
- Mice, Transgenic
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Skin
- Skin Neoplasms
- Transforming Growth Factor alpha