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Article

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

Genes & development - 1 May 1991

Vassar R, Fuchs E

Abstract excerpt

Transforming growth factor-alpha (TGF-alpha) is thought to be the major autocrine factor controlling growth in epidermal cells. To explore further the role of TGF-alpha in epidermal growth and differentiation, we used a human keratin K14 promoter to target expression of rat TGF-alpha cDNA to the stratified squamous epithelia of transgenic mice. Unexpectedly, the only regions of epidermis especially responsive to...

Topics

Animals
Animals, Newborn
Blotting, Northern
Cell Differentiation
Cell Division
Cells, Cultured
Epidermis
ErbB Receptors
Humans
Keratins
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Papilloma

Phenotype

Psoriasis

Transforming Growth Factor alpha

Wounds and Injuries

Source

Identifiers

PMID: 1709129
DOI: 10.1101/gad.5.5.714

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1709129-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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