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Article

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

Genes & development - 1 May 1991

Vassar R, Fuchs E

Abstract excerpt

Transforming growth factor-alpha (TGF-alpha) is thought to be the major autocrine factor controlling growth in epidermal cells. To explore further the role of TGF-alpha in epidermal growth and differentiation, we used a human keratin K14 promoter to target expression of rat TGF-alpha cDNA to the stratified squamous epithelia of transgenic mice. Unexpectedly, the only regions of epidermis especially responsive to...

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Identifiers

PMID: 1709129
DOI: 10.1101/gad.5.5.714

Genes

EGF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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