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Article

Molecular determinants of syntaxin 1 modulation of N-type calcium channels.

The Journal of biological chemistry - 15 Nov 2002

Jarvis Scott E, Barr Wendy, Feng Zhong-Ping, Hamid Jawed, Zamponi Gerald W

Abstract excerpt

We have previously reported that syntaxin 1A, a component of the presynaptic SNARE complex, directly modulates N-type calcium channel gating in addition to promoting tonic G-protein inhibition of the channels, whereas syntaxin 1B affects channel gating but does not support G-protein modulation (Jarvis, S. E., and Zamponi, G. W. (2001) J. Neurosci. 21, 2939-2948). Here, we have investigated the molecular...

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Identifiers

PMID: 12221094
DOI: 10.1074/jbc.M206902200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Molecular determinants of syntaxin 1 modulation of N-type calcium channels.PMID 12221094Read ↗

Functional impact of syntaxin on gating of N-type and Q-type calcium channels.Semantic proximity Read ↗

The transmembrane domain of syntaxin 1A negatively regulates voltage-sensitive Ca(2+) channels.Semantic proximity Read ↗

Syntaxin 1A regulation of weakly inactivating N-type Ca2+ channels.Semantic proximity Read ↗

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.Semantic proximity Read ↗

Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission.Semantic proximity Read ↗

Syntaxin 1A drives fusion of large dense-core neurosecretory granules into a planar lipid bilayer.Semantic proximity Read ↗

Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.Semantic proximity Read ↗

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).Semantic proximity Read ↗

Differential expression of syntaxin 1A and 1B by noradrenergic and adrenergic chromaffin cells.Semantic proximity Read ↗

Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin.Semantic proximity Read ↗

Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell.Semantic proximity Read ↗

Synapse-specific trapping of Syntaxin1a into nanoclusters by the general anesthetic isofluraneSemantic proximity Read ↗

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