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Article

Functional impact of syntaxin on gating of N-type and Q-type calcium channels.

Nature - 7 Dec 1995

Bezprozvanny I, Scheller R H, Tsien R W

Abstract excerpt

Rapid and reliable synaptic transmission depends upon the close proximity of voltage-gated calcium channels and neurotransmitter-containing vesicles in the presynaptic terminal. Although it is clear that a local Ca2+ rise conveys the crucial signal from Ca2+ channels to the exocytotic mechanism,...

Topics

Animals
Antigens, Surface
Calcium
Calcium Channels
Ion Channel Gating
Membrane Potentials
Mutation
Nerve Tissue Proteins
Oocytes
RNA, Complementary
Synaptic Vesicles
Syntaxin 1
Xenopus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8524397
DOI: 10.1038/378623a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8524397-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Functional impact of syntaxin on gating of N-type and Q-type calcium channels.PMID 8524397Read ↗

The transmembrane domain of syntaxin 1A negatively regulates voltage-sensitive Ca(2+) channels.Semantic proximity Read ↗

Syntaxin 1A regulation of weakly inactivating N-type Ca2+ channels.Semantic proximity Read ↗

Molecular determinants of syntaxin 1 modulation of N-type calcium channels.Semantic proximity Read ↗

Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin.Semantic proximity Read ↗

Syntaxins on granules promote docking of granules via interactions with munc18.Semantic proximity Read ↗

The Dual Function of the Polybasic Juxtamembrane Region of Syntaxin 1A in Clamping Spontaneous Release and Stimulating Ca2+-Triggered Release in Neuroendocrine Cells.Semantic proximity Read ↗

Intra-membrane signaling between the voltage-gated Ca2+-channel and cysteine residues of syntaxin 1A coordinates synchronous release.Semantic proximity Read ↗

Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis.Semantic proximity Read ↗

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).Semantic proximity Read ↗

Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila.Semantic proximity Read ↗

Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1.Semantic proximity Read ↗

Syntaxin 1A drives fusion of large dense-core neurosecretory granules into a planar lipid bilayer.Semantic proximity Read ↗

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