Article

Synapse-specific trapping of Syntaxin1a into nanoclusters by the general anesthetic isoflurane

2023-03-01

Abstract excerpt

<h4>Summary</h4> General anesthetics disrupt brain network dynamics through multiple pathways, predominately through post-synaptic potentiation of GABA A R and pre-synaptic inhibition of neuroexocytosis. Common clinical general anesthetic drugs, such as propofol and isoflurane, have been shown to interact and interfere with a core component of the exocytic release machinery, Syntaxin1A, to cause impaired neurotr...

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Literature Corpus work: bdb73f2d-f365-578d-9cdb-7ce226a03532
DOI: 10.1101/2023.02.27.530184

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