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Article

The transmembrane domain of syntaxin 1A negatively regulates voltage-sensitive Ca(2+) channels.

Neuroscience - 1 Jan 2001

Trus M, Wiser O, Goodnough M C, Atlas D

Abstract excerpt

Syntaxin 1A has a pronounced inhibitory effect on the activation kinetics and current amplitude of voltage-gated Ca(2+) channels. This study explores the molecular basis of syntaxin interaction with N- and Lc-type Ca(2+) channels by way of functional assays of channel gating in a Xenopus oocytes expression system. A chimera of syntaxin 1A and syntaxin 2 in which the transmembrane domain of syntaxin 2 replaced the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11377859
DOI: 10.1016/s0306-4522(01)00083-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transmembrane domain of syntaxin 1A negatively regulates voltage-sensitive Ca(2+) channels.PMID 11377859Read ↗

Functional impact of syntaxin on gating of N-type and Q-type calcium channels.Semantic proximity Read ↗

Syntaxin 1A regulation of weakly inactivating N-type Ca2+ channels.Semantic proximity Read ↗

Syntaxin 1A modulates the voltage-gated L-type calcium channel (Ca(v)1.2) in a cooperative manner.Semantic proximity Read ↗

Molecular determinants of syntaxin 1 modulation of N-type calcium channels.Semantic proximity Read ↗

Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.Semantic proximity Read ↗

Intra-membrane signaling between the voltage-gated Ca2+-channel and cysteine residues of syntaxin 1A coordinates synchronous release.Semantic proximity Read ↗

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).Semantic proximity Read ↗

Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis.Semantic proximity Read ↗

Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission.Semantic proximity Read ↗

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.Semantic proximity Read ↗

Syntaxin 1A drives fusion of large dense-core neurosecretory granules into a planar lipid bilayer.Semantic proximity Read ↗

Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.Semantic proximity Read ↗

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