Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin.

doi:10.1016/j.mcn.2011.09.007

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Article

Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin.

Molecular and cellular neurosciences - 1 Jan 2012

Masumoto Toshio, Suzuki Koichiro, Ohmori Iori, Michiue Hiroyuki, Tomizawa Kazuhito, Fujimura Atsushi, Nishiki Tei-Ichi, Matsui Hideki

Abstract excerpt

Although synaptotagmin I, which is a calcium (Ca(2+))-binding synaptic vesicle protein, may trigger soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated synaptic vesicle exocytosis, the mechanisms underlying the interaction between these proteins remain controversial, especially with respect to the identity of the protein(s) in the SNARE complex that bind(s) to synaptotagmin and...

Topics

Amino Acid Sequence
Animals
Binding Sites
Calcium
HEK293 Cells
Humans
Molecular Sequence Data
Mutation
Rats
SNARE Proteins
Synaptosomal-Associated Protein 25
Synaptotagmin I
Syntaxin 1

Source

Open in PubMed

Identifiers

PMID: 22008253
DOI: 10.1016/j.mcn.2011.09.007

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