Article
Syntaxin 1A regulation of weakly inactivating N-type Ca2+ channels.
The Journal of physiology - 15 Oct 2004
Hurley Joyce H, Cahill Anne L, Wang Meijing, Fox Aaron P
Abstract excerpt
N- and P/Q-type Ca2+ channels are abundant in nerve terminals where they interact with proteins of the release apparatus, including syntaxin 1A and SNAP-25. In previous studies on N- or P/Q-type Ca2+ channels, syntaxin 1A co-expression reduced current amplitudes, increased voltage-dependent inactivation and/or enhanced G-protein inhibition. However, these studies were conducted in Ca2+ channels that exhibited...
Topics
- Animals
- Antigens, Surface
- Calcium Channel Blockers
- Calcium Channels, N-Type
- Cattle
- Electric Conductivity
- Female
- GTP-Binding Proteins
- Mutation
- Nerve Tissue Proteins
- Oocytes