The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).

doi:10.1074/jbc.m210270200

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Article

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).

The Journal of biological chemistry - 14 Mar 2003

Cohen Roy, Elferink Lisa A, Atlas Daphne

Abstract excerpt

Biochemical and genetic studies implicate synaptotagmin (Syt 1) as a Ca2+ sensor for neuronal and neuroendocrine neurosecretion. Calcium binding to Syt 1 occurs through two cytoplasmic repeats termed the C2A and C2B domains. In addition, the C2A domain of Syt 1 has calcium-independent properties required for neurotransmitter release. For example, mutation of a polylysine motif (residues 189-192) reverses the...

Topics

Amino Acid Motifs
Animals
Antigens, Surface
Calcium
Calcium Channels
Calcium Channels, L-Type
Calcium Channels, R-Type
Calcium-Binding Proteins
Cation Transport Proteins
Cytosol
Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glutathione Transferase

Guanine Nucleotide Exchange Factors

Kinetics

Membrane Glycoproteins

Models, Biological

Mutation

Nerve Tissue Proteins

Source

Open in PubMed

Identifiers

PMID: 12645522
DOI: 10.1074/jbc.m210270200

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