Article
E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer.
International journal of cancer - 10 Oct 2002
Yabuta Tomonori, Shinmura Kazuya, Tani Masachika, Yamaguchi Satoru, Yoshimura Kimio, Katai Hitoshi, Nakajima Takashi, Mochiki Erito, Tsujinaka Toshimasa, Takami Motohisa, Hirose Kazuo, Yamaguchi Akio, Takenoshita Seiichi, Yokota Jun
Abstract excerpt
To identify germline E-cadherin mutations responsible for the predisposition to diffuse gastric cancer (DGC) among the Japanese, we screened 17 patients with familial aggregation of gastric cancer by sequencing analysis. All the patients were diagnosed with DGC and had at least 1 sibling with gas...
Topics
- Adult
- Age of Onset
- Aged
- Base Sequence
- Cadherins
- Female
- Fluorescent Antibody Technique
- Genetic Variation
- Genotype
- Humans
- Male
- Middle Aged
- Pedigree
- Stomach Neoplasms