Article
Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2001
Ascaño J J, Frierson H, Moskaluk C A, Harper J C, Roviello F, Jackson C E, El-Rifai W, Vindigni C, Tosi P, Powell S M
Abstract excerpt
Loss of the cell adhesion molecule E-cadherin has been observed in a variety of human carcinomas, and germline E-cadherin mutations have been found in several familial cases of diffuse gastric cancer. We sought to determine the prevalence and nature of E-cadherin alterations in "sporadic" gastric carcinomas. We performed comprehensive sequencing of the coding region, loss of heterozygosity (LOH) analysis, and...
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