Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma.

doi:10.1002/1097-0215(20001115)88:4<579::aid-ijc10>3.0.co;2-u

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma.

International journal of cancer - 15 Nov 2000

Fukudome Y, Yanagihara K, Takeichi M, Ito F, Shibamoto S

Abstract excerpt

The cell-cell adhesion molecule E-cadherin plays an essential role in the maintenance and function of epithelial tissues. Altered expression of E-cadherin has been implicated in tumor invasion. Analysis of mutations of the human E-cadherin gene in gastric carcinoma of the diffuse type has revealed that deletion of exon 8 or 9 in its cDNA appears to be predominant. In this study, we carried out structural and...

Topics

Animals
Base Sequence
Cadherins
Carcinoma, Signet Ring Cell
Exons
Humans
Immunohistochemistry
Intercellular Junctions
Introns
L Cells
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Weight

Mutation

Recombinant Proteins

Reverse Transcriptase Polymerase Chain Reaction

Sequence Deletion

Stomach Neoplasms

Transfection

Source

Open in PubMed

Identifiers

PMID: 11058874
DOI: 10.1002/1097-0215(20001115)88:4<579::aid-ijc10>3.0.co;2-u

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma.PMID 11058874Read ↗

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.Semantic proximity Read ↗

E‐cadherin dysfunction in gastric cancer ‐ Cellular consequences, clinical applications and open questionsSemantic proximity Read ↗

Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.Semantic proximity Read ↗

E-cadherin gene mutations in human gastric carcinoma cell lines.Semantic proximity Read ↗

E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer.Semantic proximity Read ↗

Dynamics of cell adhesion and motility in living cells is altered by a single amino acid change in E-cadherin fused to enhanced green fluorescent protein.Semantic proximity Read ↗

Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast.Semantic proximity Read ↗

Identification of eleven novel tumor-associated E-cadherin mutations. Mutations in brief no. 215. Online.Semantic proximity Read ↗

Analysis of E-cadherin in diffuse-type gastric cancer using a mutation-specific monoclonal antibody.Semantic proximity Read ↗

Desmoglein 2 is expressed abnormally rather than mutated in familial and sporadic gastric cancer.Semantic proximity Read ↗

A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination.Semantic proximity Read ↗

Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.