Article
E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma.
Cancer genetics and cytogenetics - 1 Oct 2000
Lynch H T, Grady W, Lynch J F, Tsuchiya K D, Wiesner G, Markowitz S D
Abstract excerpt
The E-cadherin mutation has been identified in a subset of families with multiple cases of diffuse gastric carcinoma. However, the true penetrance of this mutation and its association with other carcinomas in such families remains elusive. We aim to show the importance of DNA-based genetic counseling in hereditary diffuse gastric carcinoma. The proband was self-referred after three of his siblings died of diffuse...
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