Article
Clinical implications of E-cadherin associated hereditary diffuse gastric cancer.
Gut - 1 Jun 2004
Fitzgerald R C, Caldas C
Abstract excerpt
Approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).
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