Article

Structural insights into human TFIIIC promoter recognition

2023-05-16

Abstract excerpt

<h4>SUMMARY</h4> Transcription factor IIIC (TFIIIC) recruits RNA polymerase (Pol) III to most of its target genes. Recognition of intragenic A- and B-box motifs in tRNA genes by TFIIIC modules τA and τB is the first critical step for tRNA synthesis but is mechanistically poorly understood. Here, we report cryo-EM structures of the human 624 kDa TFIIIC complex unbound and bound to a tRNA gene. The τB module recogn...

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Literature Corpus work: 0a86e374-f4b2-55db-9bda-933793a46f1a
DOI: 10.1101/2023.05.16.540835

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