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Article

Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB.

Genetics - 1 Oct 1999

Wu W H, Pinto I, Chen B S, Hampsey M

Abstract excerpt

TFIIB is an essential component of the RNA polymerase II core transcriptional machinery. Previous studies have defined TFIIB domains required for interaction with other transcription factors and for basal transcription in vitro. In the study reported here we investigated the TFIIB structural requirements for transcription initiation in vivo. A library of sua7 mutations encoding altered forms of yeast TFIIB was...

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Source

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Identifiers

PMID: 10511545
DOI: 10.1093/genetics/153.2.643
PMCID: PMC1460761

Genes

SUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB.PMID 10511545Read ↗

Functional interaction between Ssu72 and the Rpb2 subunit of RNA polymerase II in Saccharomyces cerevisiae.Semantic proximity Read ↗

Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo.Semantic proximity Read ↗

Characterization of sua7 mutations defines a domain of TFIIB involved in transcription start site selection in yeast.Semantic proximity Read ↗

Functional interaction between TFIIB and the Rpb9 (Ssu73) subunit of RNA polymerase II in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1.Semantic proximity Read ↗

Functional interaction between TFIIB and the Rpb2 subunit of RNA polymerase II: implications for the mechanism of transcription initiation.Semantic proximity Read ↗

Mechanism of start site selection by RNA polymerase II: interplay between TFIIB and Ssl2/XPB helicase subunit of TFIIH.Semantic proximity Read ↗

Identification of the gene (SSU71/TFG1) encoding the largest subunit of transcription factor TFIIF as a suppressor of a TFIIB mutation in Saccharomyces cerevisiae.Semantic proximity Read ↗

The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations.Semantic proximity Read ↗

The role of TFIIB-RNA polymerase II interaction in start site selection in yeast cells.Semantic proximity Read ↗

Important role in transcription start site selection for the RNA polymerase II-TFIIE-TFIIH interface in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ssl2/TFIIH function in Transcription Start Site Scanning by RNA Polymerase II in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

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