A quantitative dissection of the DNA-binding properties of pathogenic GATA1 mutants.

Abstract excerpt

Transcription factors are modulated by a precisely coordinated set of conditions, including cell context, target sequences and their accessibility, and co-factor recruitment. Disruption to any of these conditions can dramatically affect transcription factor activity, but quantitatively characterizing the consequences of individual mutations-either in the transcription factors themselves or in their target...

Topics

• GATA1 Transcription Factor
• Humans
• Mutation
• DNA
• Protein Binding
• Animals