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Article

Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2015

Wang Tao, Wang Yongmei, Menendez Alicia, Fong Chak, Babey Muriel, Tahimic Candice G T, Cheng Zhiqiang, Li Alfred, Chang Wenhan, Bikle Daniel D

Abstract excerpt

Insulin-like growth factors (IGFs) are important local regulators during fracture healing. Although IGF1 deficiency is known to increase the risk of delayed union or non-union fractures in the elderly population, the underlying mechanisms that contribute to this defect remains unclear. In this study, IGF1 signaling during fracture healing was investigated in an osteoblast-specific IGF1 receptor (IGF1R)...

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Share to Biomechanical Phenomena
Share to Neovascularization, Pathologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Osteoblasts

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Share to Receptor, IGF Type 1

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Source

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Identifiers

PMID: 25801198
DOI: 10.1002/jbmr.2510
PMCID: PMC5690481

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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