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Article

Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms.

Endocrinology - 1 Mar 2003

Mohan Subburaman, Richman Charmaine, Guo Rongqing, Amaar Yousef, Donahue Leah Rea, Wergedal Jon, Baylink David J

Abstract excerpt

To evaluate the relative contribution of the GH/IGF axis to the development of peak bone mineral density (BMD), we measured skeletal changes in IGF-I knockout (KO), IGF-II KO, and GH-deficient lit/lit mice and their corresponding control mice at d 23 (prepubertal), 31 (pubertal), and 56 (postpubertal) in the entire femur by dual energy x-ray absorptiometry and in the mid-diaphysis by peripheral quantitative...

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Identifiers

PMID: 12586770
DOI: 10.1210/en.2002-220948
PMCID: PMC2923925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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