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Article

Loss of insulin receptor in osteoprogenitor cells impairs structural strength of bone.

Journal of diabetes research - 1 Jan 2014

Thrailkill Kathryn, Bunn R Clay, Lumpkin Charles, Wahl Elizabeth, Cockrell Gael, Morris Lindsey, Kahn C Ronald, Fowlkes John, Nyman Jeffry S

Abstract excerpt

Type 1 diabetes mellitus (T1D) is associated with decreased bone mineral density, a deficit in bone structure, and subsequently an increased risk of fragility fracture. These clinical observations, paralleled by animal models of T1D, suggest that the insulinopenia of T1D has a deleterious effect on bone. To further examine the action of insulin signaling on bone development, we generated mice with an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24963495
DOI: 10.1155/2014/703589
PMCID: PMC4052184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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