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Article

The insulin-like growth factor-I gene and osteoporosis: a critical appraisal.

Gene - 21 Nov 2005

Niu Tianhua, Rosen Clifford J

Abstract excerpt

Osteoporosis, a disorder of skeletal fragility, is common in the elderly, and its prevalence is increasing as more individuals with low bone mineral density (BMD), the strongest predictor of fracture risk, are detected. Previous basic and clinical studies imply there is a significant role for insulin-like growth factor-I (IGF-I) in determining BMD. Recently, polymorphisms upstream of the P1 promoter region of the...

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Identifiers

PMID: 16183214
DOI: 10.1016/j.gene.2005.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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