Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutants.

doi:10.1002/cm.10064

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Article

Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutants.

Cell motility and the cytoskeleton - 1 Oct 2002

Chubb Jonathan R, Wilkins Andrew, Wessels Deborah J, Soll David R, Insall Robert H

Abstract excerpt

Loss of either of the Ras pathway members RasS or GefB causes growing Dictyostelium cells to move aberrantly rapidly. In this study, we describe the changes in motility that underlie these phenotypes using computer-assisted 3D dynamic image analysis. Unexpectedly, the two mutants use different mechanisms to achieve rapid migration. The rasS(-) cells' motility is characterised by highly dynamic cell morphology,...

Topics

Animals
Cell Movement
Cell Size
Dictyostelium
Genes, Protozoan
Image Processing, Computer-Assisted
Mutation
Phenotype
Protozoan Proteins
Pseudopodia
ras GTPase-Activating Proteins

Source

Open in PubMed

Identifiers

PMID: 12211111
DOI: 10.1002/cm.10064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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