Article
Dictyostelium RasG is required for normal motility and cytokinesis, but not growth.
The Journal of cell biology - 11 Aug 1997
Tuxworth R I, Cheetham J L, Machesky L M, Spiegelmann G B, Weeks G, Insall R H
Abstract excerpt
RasG is the most abundant Ras protein in growing Dictyostelium cells and the closest relative of mammalian Ras proteins. We have generated null mutants in which expression of RasG is completely abolished. Unexpectedly, RasG- cells are able to grow at nearly wild-type rates. However, they exhibit...
Topics
- Actins
- Animals
- Cell Adhesion
- Cell Division
- Cell Polarity
- Chemotaxis
- Cytoskeleton
- Dictyostelium
- Movement
- Mutation
- Myosins
- Pseudopodia
- Transfection