Article
RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum.
Eukaryotic cell - 1 Jun 2004
Wessels Deborah, Brincks Rebecca, Kuhl Spencer, Stepanovic Vesna, Daniels Karla J, Weeks Gerald, Lim Chinten J, Spiegelman George, Fuller Danny, Iranfar Negin, Loomis William F, Soll David R
Abstract excerpt
To define the role that RasC plays in motility and chemotaxis, the behavior of a rasC null mutant, rasC-, in buffer and in response to the individual spatial, temporal, and concentration components of a natural cyclic AMP (cAMP) wave was analyzed by using computer-assisted two-dimensional and three-dimensional motion analysis systems. These quantitative studies revealed that rasC- cells translocate at the same...
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