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Article

Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit.

Genes & development - 1 Sept 2002

Littlepage Laurie E, Ruderman Joan V

Abstract excerpt

The mitotic kinase Aurora A (Aur-A) is required for formation of a bipolar mitotic spindle and accurate chromosome segregation. In somatic cells, Aur-A protein and kinase activity levels peak during mitosis, and Aur-A is degraded during mitotic exit. Here, we investigated how Aur-A protein and kinase activity levels are regulated, taking advantage of the rapid synchronous cell division cycles of Xenopus eggs and...

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Identifiers

PMID: 12208850
DOI: 10.1101/gad.1007302
PMCID: PMC186670

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit.PMID 12208850Read ↗

Requirements for the destruction of human Aurora-A.Semantic proximity Read ↗

Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.Semantic proximity Read ↗

Mitotic activation of the kinase Aurora-A requires its binding partner Bora.Semantic proximity Read ↗

Aurora A Is Essential for Early Embryonic Development and Tumor SuppressionSemantic proximity Read ↗

Aurora-A kinase is essential for bipolar spindle formation and early development.Semantic proximity Read ↗

AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylationSemantic proximity Read ↗

Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cells.Semantic proximity Read ↗

Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A ReviewSemantic proximity Read ↗

Aurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in mice.Semantic proximity Read ↗

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Aurora Kinases: Their Role in Cancer and Cellular ProcessesSemantic proximity Read ↗

Aurora-A: the maker and breaker of spindle poles.Semantic proximity Read ↗

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