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Article

Requirements for the destruction of human Aurora-A.

Journal of cell science - 1 Dec 2004

Crane Richard, Kloepfer Angela, Ruderman Joan V

Abstract excerpt

The mitotic kinase Aurora A (Aur-A) is overexpressed in a high proportion of human tumors, often in the absence of gene amplification. In somatic cells, Aur-A protein levels fall following mitosis or upon overexpression of Cdh1, an activator of the ubiquitin ligase APC/C. Thus, mutations that reduce or block the rate of Aur-A destruction might also be expected to contribute to its oncogenic potential. Previous...

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PMID: 15536123
DOI: 10.1242/jcs.01418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Requirements for the destruction of human Aurora-A.PMID 15536123Read ↗

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Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.Semantic proximity Read ↗

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Biology of Aurora A kinase: Implications in cancer manifestation and therapySemantic proximity Read ↗

Aurora Kinases: New Targets for Cancer TherapySemantic proximity Read ↗

Aurora Kinases and Potential Medical Applications of Aurora Kinase Inhibitors: A ReviewSemantic proximity Read ↗

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