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Article

Mutations in the hepatitis B virus preS2 region and abrogated receptor activity for polymerized human albumin.

Acta medica Okayama - 1 Aug 2002

Kondo Junichi, Shimomura Hiroyuki, Fujioka Shin-Ichi, Iwasaki Yoshiaki, Takagi Shinjiro, Ohnishi Yasuhiro, Tsuji Hideyuki, Sakaguchi Kosaku, Yamamoto Kazuhide, Tsuji Takao

Abstract excerpt

The preS2 region of the hepatitis B virus (HBV) has been reported to have human polymerized albumin receptor (PAR) activity, which correlates with viral replication. Here, we studied the genomic sequence of the preS region from rare patients lacking PAR activity, despite active viral replication. PAR and DNA polymerase activity was identified in 178 HBe antigen-positive HBV carriers, and a significant correlation...

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Identifiers

PMID: 12199524
DOI: 10.18926/AMO/31685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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