Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein.

doi:10.1016/0168-8278(91)90036-b

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein.

Journal of hepatology - 1 Jan 1991

Fernholz D, Stemler M, Brunetto M, Bonino F, Will H

Abstract excerpt

Mutant HBV genomes unable to produce preS2 protein were identified in the serum of a highly viremic chronic carrier. By direct sequencing of the amplified preS region and by sequencing of 50 cloned amplified preS DNA fragments all molecules were found to have deleted the preS2 translation initiat...

Topics

Adult
Base Sequence
Carrier State
Cloning, Molecular
DNA, Viral
Genome, Viral
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Male
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Protein Precursors
Viral Envelope Proteins
Virion

Source

Open in PubMed

Identifiers

PMID: 1822500
DOI: 10.1016/0168-8278(91)90036-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1822500-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics