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Article

Infectious hepatitis B virus variant defective in pre-S2 protein expression in a chronic carrier.

Virology - 1 May 1993

Fernholz D, Galle P R, Stemler M, Brunetto M, Bonino F, Will H

Abstract excerpt

All human hepatitis B viruses characterized so far express three envelope proteins, pre-S1, pre-S2, and HBs, which are believed to function as binding proteins for the cellular receptor, as targets for immune-mediated virus elimination, and in virion morphogenesis and secretion. Here we report the characterization of infectious HBV variant genomes that are unable to express a pre-S2 protein and which were derived...

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Identifiers

PMID: 8480417
DOI: 10.1006/viro.1993.1243

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